It doesn't matter if you die or do a manual reset. Your actual game will end.
You die, when your Health reaches 0 or below. You have the chance to revive your self up to two time. When you die and you cannot recover yourself, your actual game is lost and you will lose your money, bottles, status, career, investments and belongings. But you will keep your food stamps and skills.
With the stamps and your skills, you can start a new game and beat the game even faster.